Friday, October 19, 2007

Tamed twice: convergent domestication of pogo transposases in yeast and mammals

Self-promotion yes, but still a cool story (we think):

In a new paper, which appeared on October 16 in Advance Access for Molecular Biology and Evolution, we show that two different sources of normally selfish pogo-like transposases were recruited independently in the lineages of fission yeast (S. pombe) and mammals to give rise to centromere-binding proteins with important cellular functions. We call this a case of 'convergent transposase domestication'.

It is a case of convergent evolution in the sense that very similar transposases have given rise (at least) twice independently, and in separate evolutionary lineages, to proteins that bind specifically to the centromeric regions of their respective host chromosomes. Now, it is important to emphasize that the two sets of proteins (there are three in fission yeast, but only one in mammals called CENP-B) may still perform distinct functions at the centromeres. We can't answer that question yet. The chromosomal function of the 3 proteins of S. pombe is relatively well understood, but the role of mammalian CENP-B in chromosome segregation remains unclear, and even controversial. Peter Warburton has several nice review papers on the topic. We are now collaborating with Peter's lab to see if any of the many other pogo transposases domesticated in mammals have centromere-binding activity.

Congrats to Claudio and Don for their equally outstanding contribution to the study! And double congrats to Don for his first paper! The preprint can be found here.

Cool chromosome art by Alisa Poh [buy it].

152 comments:

CAE said...

tag! Hope this stimulates some more posts from you!

CedricF said...

Needless to say I've been completely swamped lately...but things are getting better now and yes time has come for more posts! Thanks for the tag!

CAE said...

I almost wrote about this paper on my new blog, but then realised that you'd already covered it. I didn't want to try to compete with the paper's actual author, so I went with another TE paper instead!

That was quite a long gap between pre- and regular publication!

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